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1994-09-03
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Document 0078
DOCN M9490078
TI Major histocompatibility complex class I-associated vaccine protection
from simian immunodeficiency virus-infected peripheral blood cells.
DT 9411
AU Heeney JL; van Els C; de Vries P; ten Haaft P; Otting N; Koornstra W;
Boes J; Dubbes R; Niphuis H; Dings M; et al; Laboratory of Viral
Pathogenesis, Biomedical Primate Research; Center, Rijswijk, The
Netherlands.
SO J Exp Med. 1994 Aug 1;180(2):769-74. Unique Identifier : AIDSLINE
MED/94321938
AB To evaluate the effectiveness of vaccine protection from infected cells
from another individual of the same species, vaccinated rhesus macaques
(Macaca mulatta) were challenged with peripheral blood mononuclear cells
from another animal diagnosed with acquired immune deficiency syndrome
(AIDS). Half of the simian immunodeficiency virus (SIV)-vaccinated
animals challenged were protected, whereas unprotected vaccinates
progressed as rapidly to AIDS. Protection was unrelated to either total
antibody titers to human cells, used in the production of the vaccine,
to HLA antibodies or to virus neutralizing activity. However, analysis
of the serotype of each animal revealed that all animals protected
against cell-associated virus challenge were those which were SIV
vaccinated and which shared a particular major histocompatibility
complex (MHC) class I allele (Mamu-A26) with the donor of the infected
cells. Cytotoxic T lymphocytes (CTL) specific for SIV envelope protein
were detected in three of four protected animals vs. one of four
unprotected animals, suggesting a possible role of MHC class
I-restricted CTL in protection from infected blood cells. These findings
have possible implications for the design of vaccines for intracellular
pathogens such as human immunodeficiency virus (HIV).
DE Amino Acid Sequence Animal Histocompatibility Antigens Class
I/*IMMUNOLOGY Human Macaca mulatta Molecular Sequence Data Sequence
Homology, Amino Acid Simian Acquired Immunodeficiency
Syndrome/*PREVENTION & CONTROL Support, Non-U.S. Gov't SIV/*IMMUNOLOGY
Viral Vaccines/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).